Hypoglycemia-activated K+ channels in hippocampal neurons

Details

Serval ID
serval:BIB_A37F4402EB6E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Hypoglycemia-activated K+ channels in hippocampal neurons
Journal
Neuroscience Letters
Author(s)
Tromba  C., Salvaggio  A., Racagni  G., Volterra  A.
ISSN
0304-3940 (Print)
Publication state
Published
Issued date
08/1992
Volume
143
Number
1-2
Pages
185-9
Notes
Journal Article --- Old month value: Aug 31
Abstract
Channels linking the electrical and metabolic activities of cells (KATP channels) have been described in various tissues, including some brain areas (hypothalamus, cerebral cortex and substantia nigra). Here we report the existence in hippocampal neurons of K+ permeant channels whose activity is regulated by extracellular glucose. They are open at the cell resting potential and respond to transient hypoglycemia with a reversible increase in activity. The one type so far characterized has a conductance of approximately 100 pS in isotonic K+, is inhibited by the sulphonylurea glibenclamide (1 microM), and is activated by the potassium channel opener lemakalim (0.1-1 microM). These data provide a direct demonstration of the presence, in hippocampal neurons, of glucose-sensitive channels that could belong to the KATP family.
Keywords
Adenosine Triphosphate/physiology Animals Benzopyrans/pharmacology Cells, Cultured Cromakalim Glucose/*pharmacology/physiology Glyburide/pharmacology Hippocampus/*cytology/embryology Hypoglycemia/*physiopathology Ion Channel Gating/drug effects Neurons/drug effects/*physiology Potassium Channels/drug effects/*physiology Pyrroles/pharmacology Rats/embryology
Pubmed
Web of science
Create date
24/01/2008 14:37
Last modification date
20/08/2019 15:09
Usage data