Hypoglycemia-activated K+ channels in hippocampal neurons

Détails

ID Serval
serval:BIB_A37F4402EB6E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hypoglycemia-activated K+ channels in hippocampal neurons
Périodique
Neuroscience Letters
Auteur⸱e⸱s
Tromba  C., Salvaggio  A., Racagni  G., Volterra  A.
ISSN
0304-3940 (Print)
Statut éditorial
Publié
Date de publication
08/1992
Volume
143
Numéro
1-2
Pages
185-9
Notes
Journal Article --- Old month value: Aug 31
Résumé
Channels linking the electrical and metabolic activities of cells (KATP channels) have been described in various tissues, including some brain areas (hypothalamus, cerebral cortex and substantia nigra). Here we report the existence in hippocampal neurons of K+ permeant channels whose activity is regulated by extracellular glucose. They are open at the cell resting potential and respond to transient hypoglycemia with a reversible increase in activity. The one type so far characterized has a conductance of approximately 100 pS in isotonic K+, is inhibited by the sulphonylurea glibenclamide (1 microM), and is activated by the potassium channel opener lemakalim (0.1-1 microM). These data provide a direct demonstration of the presence, in hippocampal neurons, of glucose-sensitive channels that could belong to the KATP family.
Mots-clé
Adenosine Triphosphate/physiology Animals Benzopyrans/pharmacology Cells, Cultured Cromakalim Glucose/*pharmacology/physiology Glyburide/pharmacology Hippocampus/*cytology/embryology Hypoglycemia/*physiopathology Ion Channel Gating/drug effects Neurons/drug effects/*physiology Potassium Channels/drug effects/*physiology Pyrroles/pharmacology Rats/embryology
Pubmed
Web of science
Création de la notice
24/01/2008 15:37
Dernière modification de la notice
20/08/2019 16:09
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