Article: article from journal or magazin.
Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate.
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Supernatants (SN) of brain macrophages in culture induce death of cerebellar granule cells in vitro, while those of astrocytes and endothelial cells do not. This toxicity can be prevented by N-methyl-D-aspartate (NMDA) receptor antagonists. Macrophage SN contain high concentrations of glutamate. Reducing the glutamate level of macrophage SN, either by exposure to astrocytes or by enzymatic degradation abolished the toxic effect. Thus, macrophage neurotoxicity is mediated by glutamate acting on NMDA receptors, and might play a role in vivo in traumatic and cerebrovascular brain lesions.
2-Amino-5-phosphonovalerate/toxicity, 6-Cyano-7-nitroquinoxaline-2,3-dione, Animals, Animals, Newborn, Astrocytes/physiology, Brain/cytology, Brain/physiology, Cells, Cultured, Dizocilpine Maleate/toxicity, Glutamates/secretion, Glutamic Acid, Macrophages/physiology, Mice, Mice, Inbred ICR, Neuroglia/physiology, Neurons/cytology, Neurons/drug effects, Neurotoxins/metabolism, Neurotoxins/toxicity, Quinoxalines/toxicity, Receptors, N-Methyl-D-Aspartate/physiology
Web of science
Last modification date