Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate.
Details
Serval ID
serval:BIB_A331DBE3F595
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate.
Journal
Neuroscience Letters
ISSN
0304-3940 (Print)
ISSN-L
0304-3940
Publication state
Published
Issued date
1991
Peer-reviewed
Oui
Volume
133
Number
2
Pages
159-162
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Supernatants (SN) of brain macrophages in culture induce death of cerebellar granule cells in vitro, while those of astrocytes and endothelial cells do not. This toxicity can be prevented by N-methyl-D-aspartate (NMDA) receptor antagonists. Macrophage SN contain high concentrations of glutamate. Reducing the glutamate level of macrophage SN, either by exposure to astrocytes or by enzymatic degradation abolished the toxic effect. Thus, macrophage neurotoxicity is mediated by glutamate acting on NMDA receptors, and might play a role in vivo in traumatic and cerebrovascular brain lesions.
Keywords
2-Amino-5-phosphonovalerate/toxicity, 6-Cyano-7-nitroquinoxaline-2,3-dione, Animals, Animals, Newborn, Astrocytes/physiology, Brain/cytology, Brain/physiology, Cells, Cultured, Dizocilpine Maleate/toxicity, Glutamates/secretion, Glutamic Acid, Macrophages/physiology, Mice, Mice, Inbred ICR, Neuroglia/physiology, Neurons/cytology, Neurons/drug effects, Neurotoxins/metabolism, Neurotoxins/toxicity, Quinoxalines/toxicity, Receptors, N-Methyl-D-Aspartate/physiology
Pubmed
Web of science
Create date
06/03/2014 16:42
Last modification date
20/08/2019 15:08
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