Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate.
Détails
ID Serval
serval:BIB_A331DBE3F595
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate.
Périodique
Neuroscience Letters
ISSN
0304-3940 (Print)
ISSN-L
0304-3940
Statut éditorial
Publié
Date de publication
1991
Peer-reviewed
Oui
Volume
133
Numéro
2
Pages
159-162
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Supernatants (SN) of brain macrophages in culture induce death of cerebellar granule cells in vitro, while those of astrocytes and endothelial cells do not. This toxicity can be prevented by N-methyl-D-aspartate (NMDA) receptor antagonists. Macrophage SN contain high concentrations of glutamate. Reducing the glutamate level of macrophage SN, either by exposure to astrocytes or by enzymatic degradation abolished the toxic effect. Thus, macrophage neurotoxicity is mediated by glutamate acting on NMDA receptors, and might play a role in vivo in traumatic and cerebrovascular brain lesions.
Mots-clé
2-Amino-5-phosphonovalerate/toxicity, 6-Cyano-7-nitroquinoxaline-2,3-dione, Animals, Animals, Newborn, Astrocytes/physiology, Brain/cytology, Brain/physiology, Cells, Cultured, Dizocilpine Maleate/toxicity, Glutamates/secretion, Glutamic Acid, Macrophages/physiology, Mice, Mice, Inbred ICR, Neuroglia/physiology, Neurons/cytology, Neurons/drug effects, Neurotoxins/metabolism, Neurotoxins/toxicity, Quinoxalines/toxicity, Receptors, N-Methyl-D-Aspartate/physiology
Pubmed
Web of science
Création de la notice
06/03/2014 16:42
Dernière modification de la notice
20/08/2019 15:08