Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes
Details
Serval ID
serval:BIB_A2D90F97BE19
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes
Journal
Neuroscience Letters
ISSN
0304-3940 (Print)
Publication state
Published
Issued date
03/1995
Volume
188
Number
2
Pages
109-12
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 24
Research Support, Non-U.S. Gov't --- Old month value: Mar 24
Abstract
Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC50 of 1.5 microM. A pharmacological analysis indicates an involvement of purinergic P2Y receptors in this action of ATP. Application of either arachidonic acid (AA), or certain unsaturated fatty acids, also results in glycogen breakdown. The EC50 of AA is approximately 50 microM. Thus ATP and AA can be added to the list of neuroactive agents that control glycogen levels in astrocytes, which includes noradrenaline, vasoactive intestinal peptide (VIP), adenosine and histamine.
Keywords
Adenosine Triphosphate/*pharmacology
Animals
Arachidonic Acid/*pharmacology
Astrocytes/*metabolism
Cells, Cultured
Cerebral Cortex/cytology/*metabolism
Glycogen/*metabolism
Mice
Mice, Inbred Strains
Receptors, Purinergic/physiology
Pubmed
Web of science
Create date
24/01/2008 14:16
Last modification date
20/08/2019 16:08