Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

Détails

ID Serval
serval:BIB_A2D90F97BE19
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes
Périodique
Neuroscience Letters
Auteur⸱e⸱s
Sorg  O., Pellerin  L., Stolz  M., Beggah  S., Magistretti  P. J.
ISSN
0304-3940 (Print)
Statut éditorial
Publié
Date de publication
03/1995
Volume
188
Numéro
2
Pages
109-12
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 24
Résumé
Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC50 of 1.5 microM. A pharmacological analysis indicates an involvement of purinergic P2Y receptors in this action of ATP. Application of either arachidonic acid (AA), or certain unsaturated fatty acids, also results in glycogen breakdown. The EC50 of AA is approximately 50 microM. Thus ATP and AA can be added to the list of neuroactive agents that control glycogen levels in astrocytes, which includes noradrenaline, vasoactive intestinal peptide (VIP), adenosine and histamine.
Mots-clé
Adenosine Triphosphate/*pharmacology Animals Arachidonic Acid/*pharmacology Astrocytes/*metabolism Cells, Cultured Cerebral Cortex/cytology/*metabolism Glycogen/*metabolism Mice Mice, Inbred Strains Receptors, Purinergic/physiology
Pubmed
Web of science
Création de la notice
24/01/2008 14:16
Dernière modification de la notice
20/08/2019 16:08
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