Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation.
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Download: Pais 2020 Immunity.pdf (7870.74 [Ko])
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Version: Final published version
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State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_A0FD9237651F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation.
Journal
Immunity
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
17/11/2020
Peer-reviewed
Oui
Volume
53
Number
5
Pages
985-1000.e11
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Central memory CD8 <sup>+</sup> T cells (Tcm) control systemic secondary infections and can protect from chronic infection and cancer as a result of their stem-cell-like capacity to expand, differentiate, and self-renew. Central memory is generally thought to emerge following pathogen clearance and to form based on the de-differentiation of cytolytic effector cells. Here, we uncovered rare effector-phase CD8 <sup>+</sup> T cells expressing high amounts of the transcription factor Tcf7 (Tcf1) that showed no evidence of prior cytolytic differentiation and that displayed key hallmarks of Tcm cells. These effector-phase Tcf7 <sup>hi</sup> cells quantitatively yielded Tcm cells based on lineage tracing. Mechanistically, Tcf1 counteracted the differentiation of Tcf7 <sup>hi</sup> cells and sustained the expression of conserved adult stem-cell genes that were critical for CD8 <sup>+</sup> T cell stemness. The discovery of stem-cell-like CD8 <sup>+</sup> T cells during the effector response to acute infection provides an opportunity to optimize Tcm cell formation by vaccination.
Keywords
CD8(+) T cells, Granzyme, LCMV infection, T cell factor 1 (Tcf1) (Tcf7), central memory, effector differentiation, stemness, vaccination, CD8(+) T cells
Pubmed
Web of science
Create date
09/11/2020 9:43
Last modification date
11/12/2021 7:12