Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation.
Détails
Télécharger: Pais 2020 Immunity.pdf (7870.74 [Ko])
Etat: Public
Version: Final published version
Licence: Non spécifiée
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_A0FD9237651F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation.
Périodique
Immunity
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Statut éditorial
Publié
Date de publication
17/11/2020
Peer-reviewed
Oui
Volume
53
Numéro
5
Pages
985-1000.e11
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Central memory CD8 <sup>+</sup> T cells (Tcm) control systemic secondary infections and can protect from chronic infection and cancer as a result of their stem-cell-like capacity to expand, differentiate, and self-renew. Central memory is generally thought to emerge following pathogen clearance and to form based on the de-differentiation of cytolytic effector cells. Here, we uncovered rare effector-phase CD8 <sup>+</sup> T cells expressing high amounts of the transcription factor Tcf7 (Tcf1) that showed no evidence of prior cytolytic differentiation and that displayed key hallmarks of Tcm cells. These effector-phase Tcf7 <sup>hi</sup> cells quantitatively yielded Tcm cells based on lineage tracing. Mechanistically, Tcf1 counteracted the differentiation of Tcf7 <sup>hi</sup> cells and sustained the expression of conserved adult stem-cell genes that were critical for CD8 <sup>+</sup> T cell stemness. The discovery of stem-cell-like CD8 <sup>+</sup> T cells during the effector response to acute infection provides an opportunity to optimize Tcm cell formation by vaccination.
Mots-clé
CD8(+) T cells, Granzyme, LCMV infection, T cell factor 1 (Tcf1) (Tcf7), central memory, effector differentiation, stemness, vaccination, CD8(+) T cells
Pubmed
Web of science
Création de la notice
09/11/2020 9:43
Dernière modification de la notice
11/12/2021 7:12