Central memory CD8<sup>+</sup> T cells derive from stem-like Tcf7<sup>hi</sup> effector cells in the absence of cytotoxic differentiation.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_A0FD9237651F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Central memory CD8<sup>+</sup> T cells derive from stem-like Tcf7<sup>hi</sup> effector cells in the absence of cytotoxic differentiation.
Journal
Immunity
Author(s)
Pais Ferreira D., Silva J.G., Wyss T., Fuertes Marraco S.A., Scarpellino L., Charmoy M., Maas R., Siddiqui I., Tang L., Joyce J.A., Delorenzi M., Luther S.A., Speiser D.E., Held W.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
17/11/2020
Peer-reviewed
Oui
Volume
53
Number
5
Pages
985-1000.e11
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Central memory CD8 <sup>+</sup> T cells (Tcm) control systemic secondary infections and can protect from chronic infection and cancer as a result of their stem-cell-like capacity to expand, differentiate, and self-renew. Central memory is generally thought to emerge following pathogen clearance and to form based on the de-differentiation of cytolytic effector cells. Here, we uncovered rare effector-phase CD8 <sup>+</sup> T cells expressing high amounts of the transcription factor Tcf7 (Tcf1) that showed no evidence of prior cytolytic differentiation and that displayed key hallmarks of Tcm cells. These effector-phase Tcf7 <sup>hi</sup> cells quantitatively yielded Tcm cells based on lineage tracing. Mechanistically, Tcf1 counteracted the differentiation of Tcf7 <sup>hi</sup> cells and sustained the expression of conserved adult stem-cell genes that were critical for CD8 <sup>+</sup> T cell stemness. The discovery of stem-cell-like CD8 <sup>+</sup> T cells during the effector response to acute infection provides an opportunity to optimize Tcm cell formation by vaccination.
Keywords
CD8(+) T cells, Granzyme, LCMV infection, T cell factor 1 (Tcf1) (Tcf7), central memory, effector differentiation, stemness, vaccination, CD8(+) T cells
Pubmed
Web of science
Create date
09/11/2020 9:43
Last modification date
14/01/2021 6:22
Usage data