Prognostic factors in urothelial renal pelvis and ureter tumours: a multicentre Rare Cancer Network study

Details

Serval ID
serval:BIB_9E87F3F92445
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prognostic factors in urothelial renal pelvis and ureter tumours: a multicentre Rare Cancer Network study
Journal
European Journal of Cancer
Author(s)
Ozsahin  M., Zouhair  A., Villa  S., Storme  G., Chauvet  B., Taussky  D., Gouders  D., Ries  G., Bontemps  P., Coucke  P. A., Mirimanoff  R. O.
ISSN
0959-8049 (Print)
Publication state
Published
Issued date
05/1999
Volume
35
Number
5
Pages
738-43
Notes
Journal Article
Multicenter Study --- Old month value: May
Abstract
To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter was collected in a retrospective multicentre study. 12 patients with distant metastases were excluded from the statistical evaluation. All but 3 patients underwent radical surgery: nephroureterectomy (n = 71), nephroureterectomy and lymphadenectomy (n = 20), nephroureterectomy and partial bladder resection or transurethral resection (n = 20), nephrectomy (n = 10), and ureterectomy (n = 5). Sixty-one per cent (n = 77) of the tumours were located in the renal pelvis, and 21% (n = 27) in the ureter (both in 22 [17%]). Following surgery, residual tumour was still present in 33 patients (16 microscopic and 17 macroscopic). Postoperative radiotherapy was given to 45 (36%) patients. The median follow-up period was 39 months. In a median period of 9 months, 66% of the patients relapsed (34 local, 7 locoregional, 16 regional, and 24 distant). The 5- and 10-year survival were 29% and 19%, respectively, in all patients. In univariate analyses, statistically significant factors influencing the outcome were Karnofsky index, pT-classification, pN-classification, tumour localisation, grade, and residual tumour after surgery. Multivariate analysis revealed that independent prognostic factors influencing outcome were pT-classification, the existence of residual tumour, and tumour localisation. In patients with urothelial renal pelvis and/or ureter tumours, a radical surgical attitude is mandatory; and the presence of tumour in the ureter is associated with a poorer prognosis.
Keywords
Aged Carcinoma, Transitional Cell/radiotherapy/*surgery Female Humans Kidney Neoplasms/radiotherapy/*surgery *Kidney Pelvis Male Retrospective Studies Survival Rate Treatment Outcome Ureteral Neoplasms/radiotherapy/*surgery
Pubmed
Web of science
Create date
24/01/2008 18:20
Last modification date
20/08/2019 16:04
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