Prognostic factors in urothelial renal pelvis and ureter tumours: a multicentre Rare Cancer Network study
Détails
ID Serval
serval:BIB_9E87F3F92445
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prognostic factors in urothelial renal pelvis and ureter tumours: a multicentre Rare Cancer Network study
Périodique
European Journal of Cancer
ISSN
0959-8049 (Print)
Statut éditorial
Publié
Date de publication
05/1999
Volume
35
Numéro
5
Pages
738-43
Notes
Journal Article
Multicenter Study --- Old month value: May
Multicenter Study --- Old month value: May
Résumé
To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter was collected in a retrospective multicentre study. 12 patients with distant metastases were excluded from the statistical evaluation. All but 3 patients underwent radical surgery: nephroureterectomy (n = 71), nephroureterectomy and lymphadenectomy (n = 20), nephroureterectomy and partial bladder resection or transurethral resection (n = 20), nephrectomy (n = 10), and ureterectomy (n = 5). Sixty-one per cent (n = 77) of the tumours were located in the renal pelvis, and 21% (n = 27) in the ureter (both in 22 [17%]). Following surgery, residual tumour was still present in 33 patients (16 microscopic and 17 macroscopic). Postoperative radiotherapy was given to 45 (36%) patients. The median follow-up period was 39 months. In a median period of 9 months, 66% of the patients relapsed (34 local, 7 locoregional, 16 regional, and 24 distant). The 5- and 10-year survival were 29% and 19%, respectively, in all patients. In univariate analyses, statistically significant factors influencing the outcome were Karnofsky index, pT-classification, pN-classification, tumour localisation, grade, and residual tumour after surgery. Multivariate analysis revealed that independent prognostic factors influencing outcome were pT-classification, the existence of residual tumour, and tumour localisation. In patients with urothelial renal pelvis and/or ureter tumours, a radical surgical attitude is mandatory; and the presence of tumour in the ureter is associated with a poorer prognosis.
Mots-clé
Aged
Carcinoma, Transitional Cell/radiotherapy/*surgery
Female
Humans
Kidney Neoplasms/radiotherapy/*surgery
*Kidney Pelvis
Male
Retrospective Studies
Survival Rate
Treatment Outcome
Ureteral Neoplasms/radiotherapy/*surgery
Pubmed
Web of science
Création de la notice
24/01/2008 18:20
Dernière modification de la notice
20/08/2019 16:04