Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.

Details

Serval ID
serval:BIB_9D98FAD1FFAF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.
Journal
mAbs
Author(s)
Vicari A.P., Schoepfer A.M., Meresse B., Goffin L., Léger O., Josserand S., Guégan N., Yousefi S., Straumann A., Cerf-Bensussan N., Simon H.U., Chvatchko Y.
ISSN
1942-0870 (Electronic)
ISSN-L
1942-0862
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
9
Number
6
Pages
927-944
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Interleukin-15 (IL-15) is a critical regulator of immune responses, especially at mucosal interfaces within the gastro-intestinal tract. Here, we describe the discovery and characterization of a humanized antibody to IL-15. Data from its epitope and mode of action, cell biology and primate pharmacology, as well as translational studies in human samples and in vivo proof-of-concept experiments in mouse models demonstrate the therapeutic potential of this new antibody targeting IL-15 for refractory celiac disease and eosinophilic esophagitis.

Keywords
Antibody, IL-15, celiac disease, cis, eosinophilic esophagitis, humanized, interleukin-15, trans
Pubmed
Web of science
Create date
13/06/2017 19:48
Last modification date
20/08/2019 15:03
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