Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.

Détails

ID Serval
serval:BIB_9D98FAD1FFAF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.
Périodique
mAbs
Auteur⸱e⸱s
Vicari A.P., Schoepfer A.M., Meresse B., Goffin L., Léger O., Josserand S., Guégan N., Yousefi S., Straumann A., Cerf-Bensussan N., Simon H.U., Chvatchko Y.
ISSN
1942-0870 (Electronic)
ISSN-L
1942-0862
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
9
Numéro
6
Pages
927-944
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Interleukin-15 (IL-15) is a critical regulator of immune responses, especially at mucosal interfaces within the gastro-intestinal tract. Here, we describe the discovery and characterization of a humanized antibody to IL-15. Data from its epitope and mode of action, cell biology and primate pharmacology, as well as translational studies in human samples and in vivo proof-of-concept experiments in mouse models demonstrate the therapeutic potential of this new antibody targeting IL-15 for refractory celiac disease and eosinophilic esophagitis.

Mots-clé
Antibody, IL-15, celiac disease, cis, eosinophilic esophagitis, humanized, interleukin-15, trans
Pubmed
Web of science
Création de la notice
13/06/2017 19:48
Dernière modification de la notice
20/08/2019 15:03
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