Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.
Details
Serval ID
serval:BIB_9D98FAD1FFAF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.
Journal
mAbs
ISSN
1942-0870 (Electronic)
ISSN-L
1942-0862
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
9
Number
6
Pages
927-944
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Interleukin-15 (IL-15) is a critical regulator of immune responses, especially at mucosal interfaces within the gastro-intestinal tract. Here, we describe the discovery and characterization of a humanized antibody to IL-15. Data from its epitope and mode of action, cell biology and primate pharmacology, as well as translational studies in human samples and in vivo proof-of-concept experiments in mouse models demonstrate the therapeutic potential of this new antibody targeting IL-15 for refractory celiac disease and eosinophilic esophagitis.
Keywords
Antibody, IL-15, celiac disease, cis, eosinophilic esophagitis, humanized, interleukin-15, trans
Pubmed
Web of science
Create date
13/06/2017 19:48
Last modification date
20/08/2019 15:03