Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Trends in Biochemical Sciences
Publication types: Journal Article ; Review Publication Status: ppublish
When herpes simplex virus (HSV) infects human cells, it is able to enter two modes of infection: lytic and latent. A key activator of lytic infection is a virion protein called VP16, which, upon infection of a permissive cell, forms a transcriptional regulatory complex with two cellular proteins - the POU-domain transcription factor Oct-1 and the cell-proliferation factor HCF-1 - to activate transcription of the first set of expressed viral genes. This regulatory complex, called the VP16-induced complex, reveals mechanisms of combinatorial control of transcription. The activities of Oct-1 and HCF-1 - two important regulators of cellular gene expression and proliferation - illuminate strategies by which HSV might coexist with its host.
Animals, Cell Division, DNA-Binding Proteins/metabolism, Gene Expression Regulation, Herpes Simplex Virus Protein Vmw65/chemistry, Herpes Simplex Virus Protein Vmw65/physiology, Host Cell Factor C1, Octamer Transcription Factor-1, Proteins/metabolism, Simplexvirus/metabolism, Transcription Factors/metabolism, Transcription, Genetic
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