The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.

Détails

ID Serval
serval:BIB_9D36C542E1DB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Périodique
Trends in Biochemical Sciences
Auteur(s)
Wysocka J., Herr W.
ISSN
0968-0004[print], 0968-0004[linking]
Statut éditorial
Publié
Date de publication
2003
Volume
28
Numéro
6
Pages
294-304
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
When herpes simplex virus (HSV) infects human cells, it is able to enter two modes of infection: lytic and latent. A key activator of lytic infection is a virion protein called VP16, which, upon infection of a permissive cell, forms a transcriptional regulatory complex with two cellular proteins - the POU-domain transcription factor Oct-1 and the cell-proliferation factor HCF-1 - to activate transcription of the first set of expressed viral genes. This regulatory complex, called the VP16-induced complex, reveals mechanisms of combinatorial control of transcription. The activities of Oct-1 and HCF-1 - two important regulators of cellular gene expression and proliferation - illuminate strategies by which HSV might coexist with its host.
Mots-clé
Animals, Cell Division, DNA-Binding Proteins/metabolism, Gene Expression Regulation, Herpes Simplex Virus Protein Vmw65/chemistry, Herpes Simplex Virus Protein Vmw65/physiology, Host Cell Factor C1, Octamer Transcription Factor-1, Proteins/metabolism, Simplexvirus/metabolism, Transcription Factors/metabolism, Transcription, Genetic
Pubmed
Web of science
Création de la notice
14/05/2009 12:03
Dernière modification de la notice
20/08/2019 15:03
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