GABAergic inhibition shapes behavior and neural dynamics in human visual working memory.
Details
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_9CEA36531C60
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
GABAergic inhibition shapes behavior and neural dynamics in human visual working memory.
Journal
Cerebral cortex
ISSN
1460-2199 (Electronic)
ISSN-L
1047-3211
Publication state
Published
Issued date
31/01/2024
Peer-reviewed
Oui
Volume
34
Number
2
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Neuronal inhibition, primarily mediated by GABAergic neurotransmission, is crucial for brain development and healthy cognition. Gamma-aminobutyric acid concentration levels in sensory areas have been shown to correlate with hemodynamic and oscillatory neuronal responses. How these measures relate to one another during working memory, a higher-order cognitive process, is still poorly understood. We address this gap by collecting magnetoencephalography, functional magnetic resonance imaging, and Flumazenil positron emission tomography data within the same subject cohort using an n-back working-memory paradigm. By probing the relationship between GABAA receptor distribution, neural oscillations, and Blood Oxygen Level Dependent (BOLD) modulations, we found that GABAA receptor density in higher-order cortical areas predicted the reaction times on the working-memory task and correlated positively with the peak frequency of gamma power modulations and negatively with BOLD amplitude. These findings support and extend theories linking gamma oscillations and hemodynamic responses to gamma-aminobutyric acid neurotransmission and to the excitation-inhibition balance and cognitive performance in humans. Considering the small sample size of the study, future studies should test whether these findings also hold for other, larger cohorts as well as to examine in detail how the GABAergic system and neural fluctuations jointly support working-memory task performance.
Keywords
Humans, Memory, Short-Term/physiology, Receptors, GABA-A, Magnetoencephalography/methods, Magnetic Resonance Imaging, gamma-Aminobutyric Acid, Brain/physiology, functional magnetic resonance imaging, magnetoencephalography, n-back, neurotransmission, positron emission tomography
Pubmed
Web of science
Open Access
Yes
Create date
12/01/2024 12:20
Last modification date
09/08/2024 16:03