TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).

Détails

ID Serval
serval:BIB_9C9827A6B3DC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).
Périodique
Immunity
Auteur(s)
Bodmer J.L., Burns K., Schneider P., Hofmann K., Steiner V., Thome M., Bornand T., Hahne M., Schröter M., Becker K., Wilson A., French L.E., Browning J.L., MacDonald H.R., Tschopp J.
ISSN
1074-7613 (Print)
ISSN-L
1074-7613
Statut éditorial
Publié
Date de publication
1997
Volume
6
Numéro
1
Pages
79-88
Langue
anglais
Résumé
A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified. The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1. TRAMP is abundantly expressed on thymocytes and lymphocytes. Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis. Overexpression of TRAMP leads to two major responses, NF-kappaB activation and apoptosis. TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.
Mots-clé
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Apoptosis, Apoptosis Regulatory Proteins, Carrier Proteins/metabolism, Chromosomes, Human, Pair 1, Cytoplasm/chemistry, Fas Ligand Protein, Fas-Associated Death Domain Protein, Gene Expression, Humans, Ligands, Lymphocytes/physiology, Membrane Glycoproteins/metabolism, Molecular Sequence Data, Multigene Family, NF-kappa B/physiology, RNA, Messenger/genetics, Receptors, Cell Surface/physiology, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/physiology, Receptors, Tumor Necrosis Factor, Member 25, Sequence Alignment, Sequence Homology, Amino Acid, Signal Transduction, TNF-Related Apoptosis-Inducing Ligand, Tumor Necrosis Factor-alpha/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:19
Dernière modification de la notice
20/08/2019 15:03
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