TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).

Bodmer, J.L.; Burns, K.; Schneider, P.; Hofmann, K.; Steiner, V.; Thome, M.; Bornand, T.; Hahne, M.; Schröter, M.; Becker, K.; Wilson, A.; French, L.E.; Browning, J.L.; MacDonald, H.R.; Tschopp, J.

doi:10.1016/S1074-7613(00)80244-7

TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).

Détails

Demande d'une copie

ID Serval

serval:BIB_9C9827A6B3DC

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).

Périodique

Immunity

Auteur⸱e⸱s

Bodmer J.L., Burns K., Schneider P., Hofmann K., Steiner V., Thome M., Bornand T., Hahne M., Schröter M., Becker K., Wilson A., French L.E., Browning J.L., MacDonald H.R., Tschopp J.

ISSN

1074-7613 (Print)

ISSN-L

1074-7613

Statut éditorial

Publié

Date de publication

1997

Volume

Numéro

Pages

79-88

Langue

anglais

Résumé

A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified. The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1. TRAMP is abundantly expressed on thymocytes and lymphocytes. Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis. Overexpression of TRAMP leads to two major responses, NF-kappaB activation and apoptosis. TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.

Mots-clé

Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Apoptosis, Apoptosis Regulatory Proteins, Carrier Proteins/metabolism, Chromosomes, Human, Pair 1, Cytoplasm/chemistry, Fas Ligand Protein, Fas-Associated Death Domain Protein, Gene Expression, Humans, Ligands, Lymphocytes/physiology, Membrane Glycoproteins/metabolism, Molecular Sequence Data, Multigene Family, NF-kappa B/physiology, RNA, Messenger/genetics, Receptors, Cell Surface/physiology, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/physiology, Receptors, Tumor Necrosis Factor, Member 25, Sequence Alignment, Sequence Homology, Amino Acid, Signal Transduction, TNF-Related Apoptosis-Inducing Ligand, Tumor Necrosis Factor-alpha/metabolism

OAI-PMH

oai:serval.unil.ch:BIB_9C9827A6B3DC

DOI

10.1016/S1074-7613(00)80244-7

Pubmed

9052839

Web of science

A1997XB16100008

Open Access

Oui

Création de la notice

24/01/2008 16:19