Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Médecine génomique et oncologie [Genomics medicine and oncology].
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish. pdf type: mini review
Progress in genomics with, in particular, high throughput next generation sequencing is revolutionizing oncology. The impact of these techniques is seen on the one hand the identification of germline mutations that predispose to a given type of cancer, allowing for a personalized care of patients or healthy carriers and, on the other hand, the characterization of all acquired somatic mutation of the tumor cell, opening the door to personalized treatment targeting the driver oncogenes. In both cases, next generation sequencing techniques allow a global approach whereby the integrality of the genome mutations is analyzed and correlated with the clinical data. The benefits on the quality of care delivered to our patients are extremely impressive.
Cell Transformation, Neoplastic/genetics, DNA Mutational Analysis, Forecasting, Genetic Predisposition to Disease/genetics, Genetic Predisposition to Disease/prevention & control, Genome, Human/genetics, Germ-Line Mutation/genetics, Heterozygote Detection, Humans, Individualized Medicine, Neoplasms/genetics, Neoplasms/therapy, Neoplastic Syndromes, Hereditary/diagnosis, Neoplastic Syndromes, Hereditary/genetics, Oncogenes/genetics, Switzerland
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