Médecine génomique et oncologie [Genomics medicine and oncology].

Détails

ID Serval
serval:BIB_9B0D168EBA26
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Médecine génomique et oncologie [Genomics medicine and oncology].
Périodique
Praxis
Auteur(s)
Michielin O., Coukos G.
ISSN
1661-8157 (Print)
ISSN-L
1661-8157
Statut éditorial
Publié
Date de publication
2014
Volume
103
Numéro
10
Pages
591-596
Langue
français
Notes
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish. pdf type: mini review
Résumé
Progress in genomics with, in particular, high throughput next generation sequencing is revolutionizing oncology. The impact of these techniques is seen on the one hand the identification of germline mutations that predispose to a given type of cancer, allowing for a personalized care of patients or healthy carriers and, on the other hand, the characterization of all acquired somatic mutation of the tumor cell, opening the door to personalized treatment targeting the driver oncogenes. In both cases, next generation sequencing techniques allow a global approach whereby the integrality of the genome mutations is analyzed and correlated with the clinical data. The benefits on the quality of care delivered to our patients are extremely impressive.
Mots-clé
Cell Transformation, Neoplastic/genetics, DNA Mutational Analysis, Forecasting, Genetic Predisposition to Disease/genetics, Genetic Predisposition to Disease/prevention & control, Genome, Human/genetics, Germ-Line Mutation/genetics, Heterozygote Detection, Humans, Individualized Medicine, Neoplasms/genetics, Neoplasms/therapy, Neoplastic Syndromes, Hereditary/diagnosis, Neoplastic Syndromes, Hereditary/genetics, Oncogenes/genetics, Switzerland
Pubmed
Création de la notice
10/09/2014 9:39
Dernière modification de la notice
20/08/2019 16:02
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