Thalamic control of cortical states
Details
Serval ID
serval:BIB_9AF11C303435
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Thalamic control of cortical states
Journal
Nature Neuroscience
ISSN
1097-6256
1546-1726
1546-1726
ISSN-L
1097-6256
Publication state
Published
Issued date
22/01/2012
Peer-reviewed
Oui
Volume
15
Number
3
Pages
370-372
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.
Keywords
Action Potentials/physiology, Afferent Pathways/physiology, Animals, Cortical Synchronization/physiology, Denervation, Electric Stimulation/methods, Fourier Analysis, Mice, Mice, Transgenic, Neurons/physiology, Rhodopsin/genetics, Somatosensory Cortex/cytology, Somatosensory Cortex/physiology, Thalamus/cytology, Thalamus/physiology, Vibrissae/innervation, Wakefulness, General Neuroscience
Pubmed
Web of science
Create date
09/09/2017 13:42
Last modification date
21/08/2019 5:35
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