Article: article from journal or magazin.
T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching.
Journal of Experimental Medicine
The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)] or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The antibody-producing cells arise from cognate T cell B cell interaction, revealed by the respective induction of Cgamma2a and Cgamma1 switch transcript production, on the third day after immunization. T cell proliferation and upregulation of mRNA for interferon gamma in response to MMTV(SW) and interleukin 4 in response to haptenated protein also starts during this day. It follows that there is minimal delay in these responses between T cell priming and the onset of cognate interaction between T and B cells leading to class switching and exponential growth. The Th1 or Th2 profile is at least partially established at the time of the first cognate T cell interaction with B cells in the T zone. The addition of killed Bordetella pertussis to the hapten-protein induces nonhapten-specific IgG2a and IgG1 plasma cells, whereas the anti-hapten response continues to be IgG1 dominated. This indicates that a Th2 response to hapten-protein can proceed in a node where there is substantial Th1 activity.
Animals, Bordetella pertussis/immunology, Germinal Center/immunology, Haptens/immunology, Immunoglobulin Class Switching, Interferon-gamma/biosynthesis, Interleukin-4/biosynthesis, Lymph Nodes/cytology, Lymph Nodes/immunology, Lymphocyte Activation, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Plasma Cells, Spleen/cytology, Spleen/immunology, Th1 Cells, Th2 Cells, Vaccination, gamma-Globulins/immunology
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