T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching.

Détails

Ressource 1Télécharger: 9547331_BIB_9ACADD245FD7.pdf (377.12 [Ko])
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_9ACADD245FD7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching.
Périodique
Journal of Experimental Medicine
Auteur(s)
Toellner K.M., Luther S.A., Sze D.M., Choy R.K., Taylor D.R., MacLennan I.C., Acha-Orbea H.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
1998
Volume
187
Numéro
8
Pages
1193-1204
Langue
anglais
Résumé
The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)] or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The antibody-producing cells arise from cognate T cell B cell interaction, revealed by the respective induction of Cgamma2a and Cgamma1 switch transcript production, on the third day after immunization. T cell proliferation and upregulation of mRNA for interferon gamma in response to MMTV(SW) and interleukin 4 in response to haptenated protein also starts during this day. It follows that there is minimal delay in these responses between T cell priming and the onset of cognate interaction between T and B cells leading to class switching and exponential growth. The Th1 or Th2 profile is at least partially established at the time of the first cognate T cell interaction with B cells in the T zone. The addition of killed Bordetella pertussis to the hapten-protein induces nonhapten-specific IgG2a and IgG1 plasma cells, whereas the anti-hapten response continues to be IgG1 dominated. This indicates that a Th2 response to hapten-protein can proceed in a node where there is substantial Th1 activity.
Mots-clé
Animals, Bordetella pertussis/immunology, Germinal Center/immunology, Haptens/immunology, Immunoglobulin Class Switching, Interferon-gamma/biosynthesis, Interleukin-4/biosynthesis, Lymph Nodes/cytology, Lymph Nodes/immunology, Lymphocyte Activation, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Plasma Cells, Spleen/cytology, Spleen/immunology, Th1 Cells, Th2 Cells, Vaccination, gamma-Globulins/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
20/08/2019 16:01
Données d'usage