p38 MAPK, microglial signaling, and neuropathic pain.
Details
State: Public
Version: Final published version
Serval ID
serval:BIB_9A78C2B77B39
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
p38 MAPK, microglial signaling, and neuropathic pain.
Journal
Molecular Pain
ISSN
1744-8069 (Electronic)
ISSN-L
1744-8069
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
3
Pages
33
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review Publication Status: epublish
Abstract
Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to neuropathic pain development and maintenance. We will discuss the upstream mechanisms causing p38 activation in spinal microglia after nerve injury. We will also discuss the downstream mechanisms by which p38 produces inflammatory mediators. Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management.
Keywords
Animals, Chemokines/metabolism, Chronic Disease, Disease Models, Animal, Humans, Inflammation Mediators/metabolism, Mice, Microglia/drug effects, Microglia/metabolism, Neuralgia/classification, Neuralgia/drug therapy, Pain Measurement/methods, Pyrazoles/metabolism, Pyridines/metabolism, Rats, Receptors, Chemokine/metabolism, Signal Transduction, Spinal Cord/cytology, Spinal Cord/metabolism, Spinal Nerves/injuries, Spinal Nerves/metabolism, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors, p38 Mitogen-Activated Protein Kinases/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
08/01/2014 11:27
Last modification date
20/08/2019 15:01
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