p38 MAPK, microglial signaling, and neuropathic pain.

Détails

Ressource 1Télécharger: BIB_9A78C2B77B39.P001.pdf (2185.65 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_9A78C2B77B39
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
p38 MAPK, microglial signaling, and neuropathic pain.
Périodique
Molecular Pain
Auteur⸱e⸱s
Ji R.R., Suter M.R.
ISSN
1744-8069 (Electronic)
ISSN-L
1744-8069
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
3
Pages
33
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review Publication Status: epublish
Résumé
Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to neuropathic pain development and maintenance. We will discuss the upstream mechanisms causing p38 activation in spinal microglia after nerve injury. We will also discuss the downstream mechanisms by which p38 produces inflammatory mediators. Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management.
Mots-clé
Animals, Chemokines/metabolism, Chronic Disease, Disease Models, Animal, Humans, Inflammation Mediators/metabolism, Mice, Microglia/drug effects, Microglia/metabolism, Neuralgia/classification, Neuralgia/drug therapy, Pain Measurement/methods, Pyrazoles/metabolism, Pyridines/metabolism, Rats, Receptors, Chemokine/metabolism, Signal Transduction, Spinal Cord/cytology, Spinal Cord/metabolism, Spinal Nerves/injuries, Spinal Nerves/metabolism, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors, p38 Mitogen-Activated Protein Kinases/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/01/2014 11:27
Dernière modification de la notice
20/08/2019 15:01
Données d'usage