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Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.
Antimicrobial Agents and Chemotherapy
While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37 degrees C but not at 4 degrees C. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo.
Cephalosporins/blood, Cephalosporins/chemistry, Chromatography, High Pressure Liquid, Humans, Reproducibility of Results, Temperature, Ultrafiltration
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