Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.
Détails
ID Serval
serval:BIB_9803E7334361
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.
Périodique
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804 (Print)
ISSN-L
0066-4804
Statut éditorial
Publié
Date de publication
2002
Volume
46
Numéro
11
Pages
3654-3656
Langue
anglais
Résumé
While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37 degrees C but not at 4 degrees C. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo.
Mots-clé
Cephalosporins/blood, Cephalosporins/chemistry, Chromatography, High Pressure Liquid, Humans, Reproducibility of Results, Temperature, Ultrafiltration
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:54
Dernière modification de la notice
20/08/2019 15:59
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