Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.

Bugnon, D.; Giannoni, E.; Majcherczyk, P.; Glauser, M.P.; Moreillon, P.

doi:10.1128/AAC.46.11.3654-3656.2002

Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.

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Serval ID

serval:BIB_9803E7334361

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.

Journal

Antimicrobial Agents and Chemotherapy

Author(s)

Bugnon D., Giannoni E., Majcherczyk P., Glauser M.P., Moreillon P.

ISSN

0066-4804 (Print)

ISSN-L

0066-4804

Publication state

Published

Issued date

2002

Volume

Number

Pages

3654-3656

Language

english

Abstract

While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37 degrees C but not at 4 degrees C. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo.

Keywords

Cephalosporins/blood, Cephalosporins/chemistry, Chromatography, High Pressure Liquid, Humans, Reproducibility of Results, Temperature, Ultrafiltration

OAI-PMH

oai:serval.unil.ch:BIB_9803E7334361

DOI

10.1128/AAC.46.11.3654-3656.2002

Pubmed

12384385

Web of science

000178712800053

Open Access

Yes

Create date

24/01/2008 14:54