Tachycardies ventriculaires réfractaires : quelle place pour la radiothérapie et comment ? [Refractory ventricular tachycardia: Is there a role for radiotherapy?]
Details
Serval ID
serval:BIB_97F278C48DAA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tachycardies ventriculaires réfractaires : quelle place pour la radiothérapie et comment ? [Refractory ventricular tachycardia: Is there a role for radiotherapy?]
Journal
Cancer radiotherapie
ISSN
1769-6658 (Electronic)
ISSN-L
1278-3218
Publication state
Published
Issued date
10/2020
Peer-reviewed
Oui
Volume
24
Number
6-7
Pages
534-546
Language
french
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Myocardial scar-related ventricular tachycardia is a serious and potentially life-threatening arrhythmia. The prevention of sudden rhythmic death and ventricular tachycardia recurrence relies on implantable cardioverter defibrillator (ICD), anti-arrhythmic drugs and more recently on radiofrequency catheter ablation. Nevertheless, these approaches have their own risk of adverse events and complications, with a recurrence rate up to 50 % at 2 years. Stereotactic body radiotherapy, delivered in a single dose of 25Gy, has emerged as a new therapeutic tool in the management of highly refractory ventricular tachycardia. In 2017, the very first prospective 5-patient cohort suffering from recurrent ventricular tachycardia on structural heart disease (40 % of ischemic cardiomyopathy) who benefited from cardiac stereotactic body radiotherapy was published. After stereotactic body radiotherapy, the authors observed a strong ventricular tachycardia burden reduction at 12 months, with no major side effects. Since then, around 100 cases have been described in the literature, particularly in the prospective ENCORE-VT study, with positive short- and medium-term outcomes in terms of safety and ventricular tachycardia burden reduction. Recently, another American prospective 5-patient series, published in March 2020, mitigated these results since all patients presented a ventricular tachycardia recurrence at 12 months despite an initial reduction in ventricular tachycardia burden. This article describes the use of stereotactic body radiotherapy in refractory VT, the rationale of the technique, its implementation, preliminary results and potential acute and long-term consequences.
Keywords
Catheter Ablation, Humans, Radiosurgery, Recurrence, Tachycardia, Ventricular/radiotherapy, Tachycardia, Ventricular/surgery, Ablation, Radioablation stéréotaxique, Radiothérapie stéréotaxique, Stereotactic arrhytmia radioablation (STAR), Stereotactic body radiation therapy (SBRT), Tachycardie ventriculaire, Ventricular tachycardia
Pubmed
Web of science
Create date
28/08/2020 7:19
Last modification date
04/01/2021 10:54