CD73 expression in normal and pathological human hepatobiliopancreatic tissues.

Détails

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Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_97044E671671
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CD73 expression in normal and pathological human hepatobiliopancreatic tissues.
Périodique
Cancer immunology, immunotherapy
Auteur(s)
Sciarra A., Monteiro I., Ménétrier-Caux C., Caux C., Gilbert B., Halkic N., La Rosa S., Romero P., Sempoux C., de Leval L.
ISSN
1432-0851 (Electronic)
ISSN-L
0340-7004
Statut éditorial
Publié
Date de publication
03/2019
Peer-reviewed
Oui
Volume
68
Numéro
3
Pages
467-478
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The tumor-expressed CD73 ectonucleotidase generates immune tolerance and promotes invasiveness via adenosine production from degradation of AMP. While anti-CD73 blockade treatment is a promising tool in cancer immunotherapy, a characterization of CD73 expression in human hepatobiliopancreatic system is lacking.
CD73 expression was investigated by immunohistochemistry in a variety of non-neoplastic and neoplastic conditions of the liver, pancreas, and biliary tract.
CD73 was expressed in normal hepatobiliopancreatic tissues with subcellular-specific patterns of staining: canalicular in hepatocytes, and apical in cholangiocytes and pancreatic ducts. CD73 was present in all hepatocellular carcinoma (HCC), in all pancreatic ductal adenocarcinoma (PDAC), and in the majority of intra and extrahepatic cholangiocellular carcinomas, whereas it was detected only in a subset of pancreatic neuroendocrine neoplasms and almost absent in acinar cell carcinoma. In addition to the canonical pattern of staining, an aberrant membranous and/or cytoplasmic expression was observed in invasive lesions, especially in HCC and PDAC. These two entities were also characterized by a higher extent and intensity of staining as compared to other hepatobiliopancreatic neoplasms. In PDAC, aberrant CD73 expression was inversely correlated with differentiation (p < 0.01) and was helpful to identify isolated discohesive tumor cells. In addition, increased CD73 expression was associated with reduced overall survival (HR 1.013) and loss of E-Cadherin.
Consistent CD73 expression supports the rationale for testing anti-CD73 therapies in patients with hepatobiliopancreatic malignancies. Specific patterns of expression could also be of help in the routine diagnostic workup.
Mots-clé
5'-Nucleotidase/analysis, 5'-Nucleotidase/antagonists & inhibitors, Bile Duct Neoplasms/chemistry, Bile Duct Neoplasms/mortality, Bile Duct Neoplasms/pathology, Biliary Tract/chemistry, Carcinoma, Hepatocellular/chemistry, Carcinoma, Hepatocellular/mortality, Carcinoma, Hepatocellular/pathology, Carcinoma, Pancreatic Ductal/chemistry, Carcinoma, Pancreatic Ductal/mortality, Carcinoma, Pancreatic Ductal/pathology, Cholangiocarcinoma/chemistry, Cholangiocarcinoma/mortality, Cholangiocarcinoma/pathology, Epithelial-Mesenchymal Transition, GPI-Linked Proteins/analysis, GPI-Linked Proteins/antagonists & inhibitors, Humans, Immunohistochemistry, Liver/chemistry, Liver Neoplasms/chemistry, Liver Neoplasms/mortality, Liver Neoplasms/pathology, Pancreas/chemistry, Pancreatic Neoplasms/chemistry, Pancreatic Neoplasms/mortality, Pancreatic Neoplasms/pathology, Prognosis, CD73, Cholangiocarcinoma, Ecto-5′-nucleotidase, Hepatocellular carcinoma, Pancreatic carcinoma
Pubmed
Web of science
Création de la notice
11/01/2019 8:25
Dernière modification de la notice
20/08/2019 14:59
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