Sleep disturbances and incident risk of major depressive disorder in a population-based cohort.
Details
Serval ID
serval:BIB_91F484F07506
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sleep disturbances and incident risk of major depressive disorder in a population-based cohort.
Journal
Psychiatry research
ISSN
1872-7123 (Electronic)
ISSN-L
0165-1781
Publication state
Published
Issued date
08/2024
Peer-reviewed
Oui
Volume
338
Pages
115934
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years' follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022-1.103], p = 0.002 and 1.437 [1.064-1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064-1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463-0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.
Keywords
Humans, Male, Depressive Disorder, Major/epidemiology, Female, Adult, Middle Aged, Incidence, Sleep Wake Disorders/epidemiology, Polysomnography, Cohort Studies, Sleep Initiation and Maintenance Disorders/epidemiology, Proportional Hazards Models, Surveys and Questionnaires, Risk Factors, Delta power, Depression, Electroencephalogram, Hypersomnia, Insomnia, MDD, Major depressive disorder, REM sleep, Rapid eye movements, Sleep, Sleepiness, Slow wave sleep
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2024 15:56
Last modification date
27/07/2024 7:00