Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.
Details
Serval ID
serval:BIB_91CEC9119F7E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.
Journal
Frontiers in immunology
Working group(s)
RegCOVID Study Group
Contributor(s)
Pierre-Yves B., Florian D., Paraskevas F., Benoit GER, David H., Eleftheria-Evdokia K., Oriol M., Aline M., Jean-Luc P., Matthaios P.O., Jean R., Laurence R.S., Veronique S., Eliana T., Jonathan T., Mathias V.S., Benjamin V., Peter V.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
12
Pages
666163
Language
english
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covid/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19.
Keywords
COVID-19/immunology, Humans, Influenza, Human/immunology, SARS-CoV-2/immunology, Transcriptome, COVID-19, RNA-sequencing, SARS-CoV-2, immune profiling, influenza, whole blood transcriptome
Pubmed
Web of science
Create date
25/06/2021 17:26
Last modification date
21/11/2022 8:31