Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.

Détails

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Etat: Public
Version: de l'auteur⸱e
Licence: CC BY 4.0
ID Serval
serval:BIB_91CEC9119F7E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.
Périodique
Frontiers in immunology
Auteur⸱e⸱s
Bibert S. (co-premier), Guex N. (co-premier), Lourenco J., Brahier T., Papadimitriou-Olivgeris M., Damonti L., Manuel O., Liechti R., Götz L., Tschopp J., Quinodoz M., Vollenweider P., Pagani J.L., Oddo M., Hügli O., Lamoth F., Erard V., Voide C., Delorenzi M., Rufer N., Candotti F., Rivolta C., Boillat-Blanco N. (co-dernier), Bochud P.Y. (co-dernier)
Collaborateur⸱rice⸱s
RegCOVID Study Group
Contributeur⸱rice⸱s
Pierre-Yves B., Florian D., Paraskevas F., Benoit GER, David H., Eleftheria-Evdokia K., Oriol M., Aline M., Jean-Luc P., Matthaios P.O., Jean R., Laurence R.S., Veronique S., Eliana T., Jonathan T., Mathias V.S., Benjamin V., Peter V.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2021
Peer-reviewed
Oui
Volume
12
Pages
666163
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covid/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19.
Mots-clé
COVID-19/immunology, Humans, Influenza, Human/immunology, SARS-CoV-2/immunology, Transcriptome, COVID-19, RNA-sequencing, SARS-CoV-2, immune profiling, influenza, whole blood transcriptome
Pubmed
Web of science
Création de la notice
25/06/2021 17:26
Dernière modification de la notice
21/11/2022 8:31
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