Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.

Details

Serval ID
serval:BIB_91CEC9119F7E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.
Journal
Frontiers in immunology
Author(s)
Bibert S. (co-first), Guex N. (co-first), Lourenco J., Brahier T., Papadimitriou-Olivgeris M., Damonti L., Manuel O., Liechti R., Götz L., Tschopp J., Quinodoz M., Vollenweider P., Pagani J.L., Oddo M., Hügli O., Lamoth F., Erard V., Voide C., Delorenzi M., Rufer N., Candotti F., Rivolta C., Boillat-Blanco N. (co-last), Bochud P.Y. (co-last)
Working group(s)
RegCOVID Study Group
Contributor(s)
Pierre-Yves B., Florian D., Paraskevas F., Benoit GER, David H., Eleftheria-Evdokia K., Oriol M., Aline M., Jean-Luc P., Matthaios P.O., Jean R., Laurence R.S., Veronique S., Eliana T., Jonathan T., Mathias V.S., Benjamin V., Peter V.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
12
Pages
666163
Language
english
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covid/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19.
Keywords
COVID-19/immunology, Humans, Influenza, Human/immunology, SARS-CoV-2/immunology, Transcriptome, COVID-19, RNA-sequencing, SARS-CoV-2, immune profiling, influenza, whole blood transcriptome
Pubmed
Web of science
Create date
25/06/2021 18:26
Last modification date
06/07/2021 6:35
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