Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man.
Details
Serval ID
serval:BIB_912A673FEC97
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man.
Journal
Psychopharmacology
ISSN
0033-3158 (Print)
ISSN-L
0033-3158
Publication state
Published
Issued date
1992
Volume
108
Number
3
Pages
380-386
Language
english
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of the 5-HT1A partial agonist, buspirone, or placebo. The difference in rCBF, before and after drug, (buspirone versus placebo) was used to identify brain areas affected by buspirone. Buspirone-induced changes in rCBF were studied under two behavioural conditions (5 word-list learning and 15 word-list learning). Compared to placebo, buspirone increased blood flow in the cuneus during both behavioural states. However, decreases in blood flow, centred in the left dorso-lateral prefrontal cortex and posterior cingulate cortex, were only observed under one of the two behavioural conditions. It is concluded that buspirone-induced alterations in regional cerebral blood flow are better understood, not in relation to the known distribution of monoamine neurotransmitter systems (particularly ascending 5-HT projections), but rather in relation to putative neuronal circuits possibly many synapses "downstream" of buspirone's pharmacological site of action.
Keywords
Adult, Arousal/drug effects, Buspirone/adverse effects, Buspirone/blood, Cerebrovascular Circulation/drug effects, Growth Hormone/blood, Humans, Male, Prolactin/blood, Receptors, Serotonin/drug effects, Stress, Psychological/blood, Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/09/2011 17:37
Last modification date
20/08/2019 15:54