Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man.

Détails

ID Serval
serval:BIB_912A673FEC97
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man.
Périodique
Psychopharmacology
Auteur⸱e⸱s
Grasby P.M., Friston K.J., Bench C., Cowen P.J., Frith C.D., Liddle P.F., Frackowiak R.S., Dolan R.J.
ISSN
0033-3158 (Print)
ISSN-L
0033-3158
Statut éditorial
Publié
Date de publication
1992
Volume
108
Numéro
3
Pages
380-386
Langue
anglais
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of the 5-HT1A partial agonist, buspirone, or placebo. The difference in rCBF, before and after drug, (buspirone versus placebo) was used to identify brain areas affected by buspirone. Buspirone-induced changes in rCBF were studied under two behavioural conditions (5 word-list learning and 15 word-list learning). Compared to placebo, buspirone increased blood flow in the cuneus during both behavioural states. However, decreases in blood flow, centred in the left dorso-lateral prefrontal cortex and posterior cingulate cortex, were only observed under one of the two behavioural conditions. It is concluded that buspirone-induced alterations in regional cerebral blood flow are better understood, not in relation to the known distribution of monoamine neurotransmitter systems (particularly ascending 5-HT projections), but rather in relation to putative neuronal circuits possibly many synapses "downstream" of buspirone's pharmacological site of action.
Mots-clé
Adult, Arousal/drug effects, Buspirone/adverse effects, Buspirone/blood, Cerebrovascular Circulation/drug effects, Growth Hormone/blood, Humans, Male, Prolactin/blood, Receptors, Serotonin/drug effects, Stress, Psychological/blood, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
25/09/2011 16:37
Dernière modification de la notice
20/08/2019 14:54
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