PPAR gamma: ally and foe in bone metabolism.
Details
Serval ID
serval:BIB_8FFE2B0EC4D7
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
PPAR gamma: ally and foe in bone metabolism.
Journal
Cell Metabolism
ISSN
1550-4131[print]
Publication state
Published
Issued date
2008
Volume
7
Number
3
Pages
188-190
Language
english
Abstract
Bone homeostasis is a well-balanced process that is largely dependent on the contribution of both bone-forming osteoblasts and bone-resorbing osteoclasts. A new study (Wan et al., 2007) suggests a previously unsuspected role for the transcription factor PPARgamma in promoting bone progenitors to the osteoclastic lineage.
Keywords
Animals, Bone Remodeling/drug effects, Bone Resorption/metabolism, Cell Differentiation, Cell Lineage, Hematopoietic Stem Cells/metabolism, Humans, Mice, Mice, Knockout, NF-kappa B/metabolism, Osteoblasts/drug effects, Osteoblasts/metabolism, Osteoclasts/drug effects, Osteoclasts/metabolism, Osteopetrosis/metabolism, PPAR gamma/agonists, PPAR gamma/genetics, Proto-Oncogene Proteins c-fos/metabolism, Signal Transduction/drug effects, Thiazolidinediones/pharmacology
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2009 23:14
Last modification date
20/08/2019 15:53
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