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Copper acquisition by the SenC protein regulates aerobic respiration in Pseudomonas aeruginosa PAO1.
FEMS microbiology letters
Aerobic respiration of Pseudomonas aeruginosa involves four terminal oxidases belonging to the heme-copper family (that is, three cytochrome c oxidases and one quinol oxidase) plus one copper-independent, cyanide-insensitive quinol oxidase (CIO). The PA0114 gene encoding an SCO1/SenC-type protein, which is known to be important for copper delivery to cytochrome c in yeast, Rhodobacter spp. and Agrobacterium tumefaciens, was found to be important for copper acquisition and aerobic respiration in P. aeruginosa. A PA0114 (senC) mutant grew poorly in low-copper media and had low cytochrome cbb(3)-type oxidase activity, but expressed CIO at increased levels, by comparison with the wild-type PAO1. Addition of copper reversed these phenotypes, suggesting that periplasmic copper capture by the SenC protein helps P. aeruginosa to adapt to copper deprivation.
Aerobiosis, Amino Acid Sequence, Bacterial Proteins/genetics, Bacterial Proteins/metabolism, Copper/metabolism, Gene Deletion, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Oxidoreductases/metabolism, Pseudomonas aeruginosa/genetics, Pseudomonas aeruginosa/growth & development, Sequence Alignment
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