Copper acquisition by the SenC protein regulates aerobic respiration in Pseudomonas aeruginosa PAO1.

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ID Serval
serval:BIB_8FED5154B9BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Copper acquisition by the SenC protein regulates aerobic respiration in Pseudomonas aeruginosa PAO1.
Périodique
FEMS microbiology letters
Auteur⸱e⸱s
Frangipani E., Haas D.
ISSN
1574-6968[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
298
Numéro
2
Pages
234-240
Langue
anglais
Résumé
Aerobic respiration of Pseudomonas aeruginosa involves four terminal oxidases belonging to the heme-copper family (that is, three cytochrome c oxidases and one quinol oxidase) plus one copper-independent, cyanide-insensitive quinol oxidase (CIO). The PA0114 gene encoding an SCO1/SenC-type protein, which is known to be important for copper delivery to cytochrome c in yeast, Rhodobacter spp. and Agrobacterium tumefaciens, was found to be important for copper acquisition and aerobic respiration in P. aeruginosa. A PA0114 (senC) mutant grew poorly in low-copper media and had low cytochrome cbb(3)-type oxidase activity, but expressed CIO at increased levels, by comparison with the wild-type PAO1. Addition of copper reversed these phenotypes, suggesting that periplasmic copper capture by the SenC protein helps P. aeruginosa to adapt to copper deprivation.
Mots-clé
Aerobiosis, Amino Acid Sequence, Bacterial Proteins/genetics, Bacterial Proteins/metabolism, Copper/metabolism, Gene Deletion, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Oxidoreductases/metabolism, Pseudomonas aeruginosa/genetics, Pseudomonas aeruginosa/growth & development, Sequence Alignment
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/02/2010 17:00
Dernière modification de la notice
14/02/2022 7:56
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