Copper acquisition by the SenC protein regulates aerobic respiration in Pseudomonas aeruginosa PAO1.

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Serval ID
serval:BIB_8FED5154B9BB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Copper acquisition by the SenC protein regulates aerobic respiration in Pseudomonas aeruginosa PAO1.
Journal
FEMS microbiology letters
Author(s)
Frangipani E., Haas D.
ISSN
1574-6968[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
298
Number
2
Pages
234-240
Language
english
Abstract
Aerobic respiration of Pseudomonas aeruginosa involves four terminal oxidases belonging to the heme-copper family (that is, three cytochrome c oxidases and one quinol oxidase) plus one copper-independent, cyanide-insensitive quinol oxidase (CIO). The PA0114 gene encoding an SCO1/SenC-type protein, which is known to be important for copper delivery to cytochrome c in yeast, Rhodobacter spp. and Agrobacterium tumefaciens, was found to be important for copper acquisition and aerobic respiration in P. aeruginosa. A PA0114 (senC) mutant grew poorly in low-copper media and had low cytochrome cbb(3)-type oxidase activity, but expressed CIO at increased levels, by comparison with the wild-type PAO1. Addition of copper reversed these phenotypes, suggesting that periplasmic copper capture by the SenC protein helps P. aeruginosa to adapt to copper deprivation.
Keywords
Aerobiosis, Amino Acid Sequence, Bacterial Proteins/genetics, Bacterial Proteins/metabolism, Copper/metabolism, Gene Deletion, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Oxidoreductases/metabolism, Pseudomonas aeruginosa/genetics, Pseudomonas aeruginosa/growth & development, Sequence Alignment
Pubmed
Web of science
Open Access
Yes
Create date
03/02/2010 18:00
Last modification date
25/09/2019 7:09
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