Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma

Détails

ID Serval
serval:BIB_8DFFCB8116B7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma
Périodique
Nature Medicine
Auteur(s)
Ruegg  C., Yilmaz  A., Bieler  G., Bamat  J., Chaubert  P., Lejeune  F. J.
ISSN
1078-8956 (Print)
Statut éditorial
Publié
Date de publication
04/1998
Volume
4
Numéro
4
Pages
408-14
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
Administration of tumor necrosis factor (TNF) and gamma interferon (IFN-gamma) to melanoma patients causes selective disruption of the tumor vasculature but the mechanism of this disruption is unknown. Here we report that exposure of human endothelial cells to TNF and IFN-gamma results in a reduced activation of integrin alphaVbeta3, an adhesion receptor that plays a key role in tumor angiogenesis, leading to a decreased alphaVbeta3-dependent endothelial cell adhesion and survival. Detachment and apoptosis of angiogenic endothelial cells was demonstrated in vivo in melanoma metastases of patients treated with TNF and IFN-gamma. These results implicate integrin alphaVbeta3 in the anti-vascular activity of TNF and IFN-gamma and demonstrate a new mechanism by which cytokines control cell adhesion.
Mots-clé
Apoptosis/drug effects Biopsy Cell Adhesion/drug effects Cell Division/drug effects Cell Survival/drug effects Cells, Cultured Endothelium, Vascular/cytology/*drug effects/physiology Humans Interferon Type II/*pharmacology/therapeutic use Melanoma/*blood supply/pathology/therapy Neoplasm Metastasis Neovascularization, Pathologic/psychology Receptors, Vitronectin/drug effects/*physiology Recombinant Proteins/pharmacology Tumor Necrosis Factor-alpha/*pharmacology/therapeutic use Umbilical Veins
Pubmed
Web of science
Création de la notice
28/01/2008 9:36
Dernière modification de la notice
03/03/2018 19:17
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