Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma
Détails
ID Serval
serval:BIB_8DFFCB8116B7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma
Périodique
Nature Medicine
ISSN
1078-8956 (Print)
Statut éditorial
Publié
Date de publication
04/1998
Volume
4
Numéro
4
Pages
408-14
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
Administration of tumor necrosis factor (TNF) and gamma interferon (IFN-gamma) to melanoma patients causes selective disruption of the tumor vasculature but the mechanism of this disruption is unknown. Here we report that exposure of human endothelial cells to TNF and IFN-gamma results in a reduced activation of integrin alphaVbeta3, an adhesion receptor that plays a key role in tumor angiogenesis, leading to a decreased alphaVbeta3-dependent endothelial cell adhesion and survival. Detachment and apoptosis of angiogenic endothelial cells was demonstrated in vivo in melanoma metastases of patients treated with TNF and IFN-gamma. These results implicate integrin alphaVbeta3 in the anti-vascular activity of TNF and IFN-gamma and demonstrate a new mechanism by which cytokines control cell adhesion.
Mots-clé
Apoptosis/drug effects
Biopsy
Cell Adhesion/drug effects
Cell Division/drug effects
Cell Survival/drug effects
Cells, Cultured
Endothelium, Vascular/cytology/*drug effects/physiology
Humans
Interferon Type II/*pharmacology/therapeutic use
Melanoma/*blood supply/pathology/therapy
Neoplasm Metastasis
Neovascularization, Pathologic/psychology
Receptors, Vitronectin/drug effects/*physiology
Recombinant Proteins/pharmacology
Tumor Necrosis Factor-alpha/*pharmacology/therapeutic use
Umbilical Veins
Pubmed
Web of science
Création de la notice
28/01/2008 9:36
Dernière modification de la notice
20/08/2019 15:51