Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_8C970D1E5DF9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.
Journal
European journal of nutrition
Author(s)
Llanaj E., Dejanovic G.M., Valido E., Bano A., Gamba M., Kastrati L., Minder B., Stojic S., Voortman T., Marques-Vidal P., Stoyanov J., Metzger B., Glisic M., Kern H., Muka T.
ISSN
1436-6215 (Electronic)
ISSN-L
1436-6207
Publication state
Published
Issued date
06/2022
Peer-reviewed
Oui
Volume
61
Number
4
Pages
1749-1778
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Review ; Systematic Review
Publication Status: ppublish
Abstract
Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms.
We included randomized clinical trials (RCTs) that assessed the effect of oat, oat beta-glucan-rich extracts or avenanthramides on CVD risk markers.
Seventy-four RCTs, including 4937 predominantly hypercholesterolemic, obese subjects, with mild metabolic disturbances, were included in the systematic review. Of these, 59 RCTs contributed to the meta-analyses. Subjects receiving an OSI, compared to control arms without oats, had improved levels of total cholesterol (TC) [weighted mean difference and (95% CI) - 0.42 mmol/L, (- 0.61; - 0.22)], LDL cholesterol [- 0.29 mmol/L, (- 0.37; - 0.20)], glucose [- 0.25 nmol/L, (- 0.36; - 0.14)], body mass index [- 0.13 kg/m <sup>2</sup> , (- 0.26; - 0.01)], weight [- 0.94 kg, (- 1.84: - 0.05)], and waist circumference [- 1.06 cm, (- 1.85; - 0.27)]. RCTs on inflammation and/or oxidative stress markers were scarce and with inconsistent findings. RCTs comparing an OSI to heterogeneous interventions (e.g., wheat, eggs, rice, etc.), showed lowered levels of glycated haemoglobin, diastolic blood pressure, HDL cholesterol and apolipoprotein B. The majority of included RCTs (81.1%) had some concerns for risk of bias.
Dietary OSIs resulted in lowered levels of blood lipids and improvements in anthropometric parameters among participants with predominantly mild metabolic disturbances, regardless of dietary background or control. Further high-quality trials are warranted to establish the role of OSIs on blood pressure, glucose homeostasis and inflammation markers.
Keywords
Adult, Avena, Biomarkers, Cardiovascular Diseases/prevention & control, Cholesterol, Dietary Supplements, Glucose, Humans, Inflammation, Randomized Controlled Trials as Topic, Cardiovascular diseases, Interventions, Nutrition, Oats, Risk markers, Supplementation
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2022 13:51
Last modification date
23/11/2022 7:13
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