Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_8C970D1E5DF9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.
Périodique
European journal of nutrition
Auteur⸱e⸱s
Llanaj E., Dejanovic G.M., Valido E., Bano A., Gamba M., Kastrati L., Minder B., Stojic S., Voortman T., Marques-Vidal P., Stoyanov J., Metzger B., Glisic M., Kern H., Muka T.
ISSN
1436-6215 (Electronic)
ISSN-L
1436-6207
Statut éditorial
Publié
Date de publication
06/2022
Peer-reviewed
Oui
Volume
61
Numéro
4
Pages
1749-1778
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Review ; Systematic Review
Publication Status: ppublish
Résumé
Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms.
We included randomized clinical trials (RCTs) that assessed the effect of oat, oat beta-glucan-rich extracts or avenanthramides on CVD risk markers.
Seventy-four RCTs, including 4937 predominantly hypercholesterolemic, obese subjects, with mild metabolic disturbances, were included in the systematic review. Of these, 59 RCTs contributed to the meta-analyses. Subjects receiving an OSI, compared to control arms without oats, had improved levels of total cholesterol (TC) [weighted mean difference and (95% CI) - 0.42 mmol/L, (- 0.61; - 0.22)], LDL cholesterol [- 0.29 mmol/L, (- 0.37; - 0.20)], glucose [- 0.25 nmol/L, (- 0.36; - 0.14)], body mass index [- 0.13 kg/m <sup>2</sup> , (- 0.26; - 0.01)], weight [- 0.94 kg, (- 1.84: - 0.05)], and waist circumference [- 1.06 cm, (- 1.85; - 0.27)]. RCTs on inflammation and/or oxidative stress markers were scarce and with inconsistent findings. RCTs comparing an OSI to heterogeneous interventions (e.g., wheat, eggs, rice, etc.), showed lowered levels of glycated haemoglobin, diastolic blood pressure, HDL cholesterol and apolipoprotein B. The majority of included RCTs (81.1%) had some concerns for risk of bias.
Dietary OSIs resulted in lowered levels of blood lipids and improvements in anthropometric parameters among participants with predominantly mild metabolic disturbances, regardless of dietary background or control. Further high-quality trials are warranted to establish the role of OSIs on blood pressure, glucose homeostasis and inflammation markers.
Mots-clé
Adult, Avena, Biomarkers, Cardiovascular Diseases/prevention & control, Cholesterol, Dietary Supplements, Glucose, Humans, Inflammation, Randomized Controlled Trials as Topic, Cardiovascular diseases, Interventions, Nutrition, Oats, Risk markers, Supplementation
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/01/2022 13:51
Dernière modification de la notice
23/11/2022 7:13
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