Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1.

Détails

ID Serval
serval:BIB_8B82920E9F25
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1.
Périodique
Immunity
Auteur(s)
Crouse J., Bedenikovic G., Wiesel M., Ibberson M., Xenarios I., Von Laer D., Kalinke U., Vivier E., Jonjic S., Oxenius A.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
40
Numéro
6
Pages
961-973
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Direct type I interferon (IFN) signaling on T cells is necessary for the proper expansion, differentiation, and survival of responding T cells following infection with viruses prominently inducing type I IFN. The reasons for the abortive response of T cells lacking the type I IFN receptor (Ifnar1(-/-)) remain unclear. We report here that Ifnar1(-/-) T cells were highly susceptible to natural killer (NK) cell-mediated killing in a perforin-dependent manner. Depletion of NK cells prior to lymphocytic choriomeningitis virus (LCMV) infection completely restored the early expansion of Ifnar1(-/-) T cells. Ifnar1(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack. Thus, direct sensing of type I IFNs by T cells protects them from NK cell killing by regulating the expression of NCR1 ligands, thereby revealing a mechanism by which T cells can evade the potent cytotoxic activity of NK cells.
Mots-clé
Adoptive Transfer, Animals, Antigens, Ly/immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Cells, Cultured, Cytotoxicity, Immunologic, Immunity, Innate, Interferon Type I/immunology, Killer Cells, Natural/immunology, Lymphocyte Activation/immunology, Lymphocytic Choriomeningitis/immunology, Lymphocytic Choriomeningitis/virology, Lymphocytic choriomeningitis virus/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Natural Cytotoxicity Triggering Receptor 1/immunology, Perforin/biosynthesis, Receptor, Interferon alpha-beta/genetics, Rhabdoviridae Infections/immunology, Signal Transduction/immunology, Vesiculovirus/genetics, Vesiculovirus/immunology, Virus Replication/immunology
Pubmed
Web of science
Création de la notice
02/10/2014 18:35
Dernière modification de la notice
03/03/2018 19:11
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