Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1.
Détails
ID Serval
serval:BIB_8B82920E9F25
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1.
Périodique
Immunity
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
40
Numéro
6
Pages
961-973
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Direct type I interferon (IFN) signaling on T cells is necessary for the proper expansion, differentiation, and survival of responding T cells following infection with viruses prominently inducing type I IFN. The reasons for the abortive response of T cells lacking the type I IFN receptor (Ifnar1(-/-)) remain unclear. We report here that Ifnar1(-/-) T cells were highly susceptible to natural killer (NK) cell-mediated killing in a perforin-dependent manner. Depletion of NK cells prior to lymphocytic choriomeningitis virus (LCMV) infection completely restored the early expansion of Ifnar1(-/-) T cells. Ifnar1(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack. Thus, direct sensing of type I IFNs by T cells protects them from NK cell killing by regulating the expression of NCR1 ligands, thereby revealing a mechanism by which T cells can evade the potent cytotoxic activity of NK cells.
Mots-clé
Adoptive Transfer, Animals, Antigens, Ly/immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Cells, Cultured, Cytotoxicity, Immunologic, Immunity, Innate, Interferon Type I/immunology, Killer Cells, Natural/immunology, Lymphocyte Activation/immunology, Lymphocytic Choriomeningitis/immunology, Lymphocytic Choriomeningitis/virology, Lymphocytic choriomeningitis virus/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Natural Cytotoxicity Triggering Receptor 1/immunology, Perforin/biosynthesis, Receptor, Interferon alpha-beta/genetics, Rhabdoviridae Infections/immunology, Signal Transduction/immunology, Vesiculovirus/genetics, Vesiculovirus/immunology, Virus Replication/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/10/2014 18:35
Dernière modification de la notice
20/08/2019 15:50