Clozapin-induzierter cholestatischer Ikterus: ein Fallbericht. [Clozapine-induced cholestatic jaundice: a case report]

Details

Serval ID
serval:BIB_8989BDD35F38
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Clozapin-induzierter cholestatischer Ikterus: ein Fallbericht. [Clozapine-induced cholestatic jaundice: a case report]
Journal
Zeitschrift fur Gastroenterologie
Author(s)
Dorta  G., Siebenmann  R., Frohli  P., Freytag  P., Koelz  H. R.
ISSN
0044-2771 (Print)
Publication state
Published
Issued date
07/1989
Volume
27
Number
7
Pages
388-90
Notes
Case Reports
English Abstract
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
We report on a patient who became jaundiced during treatment with clozapine (Leponex). Histologically, cholestatic hepatitis with single-cell necroses of hepatocytes and infiltration of the portal zones with eosinophilic granulocytes were found. The patient recovered after discontinuation of clozapine, and liver function tests returned to normal within 4 weeks. This adverse effect of clozapine suggests that this "atypical" tricyclic neuroleptic resembles the phenothiazines both with regard to therapeutic spectrum and side effects.
Keywords
Aged Autistic Disorder/*drug therapy Cholestasis, Intrahepatic/*chemically induced/pathology Clozapine/*adverse effects/therapeutic use Dibenzazepines/*adverse effects Female Humans Liver/pathology
Pubmed
Web of science
Create date
25/01/2008 16:48
Last modification date
20/08/2019 15:48
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