Clozapin-induzierter cholestatischer Ikterus: ein Fallbericht. [Clozapine-induced cholestatic jaundice: a case report]
Détails
ID Serval
serval:BIB_8989BDD35F38
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Clozapin-induzierter cholestatischer Ikterus: ein Fallbericht. [Clozapine-induced cholestatic jaundice: a case report]
Périodique
Zeitschrift fur Gastroenterologie
ISSN
0044-2771 (Print)
Statut éditorial
Publié
Date de publication
07/1989
Volume
27
Numéro
7
Pages
388-90
Notes
Case Reports
English Abstract
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
English Abstract
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
We report on a patient who became jaundiced during treatment with clozapine (Leponex). Histologically, cholestatic hepatitis with single-cell necroses of hepatocytes and infiltration of the portal zones with eosinophilic granulocytes were found. The patient recovered after discontinuation of clozapine, and liver function tests returned to normal within 4 weeks. This adverse effect of clozapine suggests that this "atypical" tricyclic neuroleptic resembles the phenothiazines both with regard to therapeutic spectrum and side effects.
Mots-clé
Aged
Autistic Disorder/*drug therapy
Cholestasis, Intrahepatic/*chemically induced/pathology
Clozapine/*adverse effects/therapeutic use
Dibenzazepines/*adverse effects
Female
Humans
Liver/pathology
Pubmed
Web of science
Création de la notice
25/01/2008 16:48
Dernière modification de la notice
20/08/2019 15:48