A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.

Details

Serval ID
serval:BIB_891F521C981B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.
Journal
Immunity
Author(s)
Chalifour A., Scarpellino L., Back J., Brodin P., Devèvre E., Gros F., Lévy F., Leclercq G., Höglund P., Beermann F., Held W.
ISSN
1097-4180[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
30
Number
3
Pages
337-347
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Natural killer (NK) cells show enhanced functional competence when they express inhibitory receptors specific for inherited major histocompatibility complex class I (MHC-I) molecules. Current models imply that NK cell education requires an interaction of inhibitory receptors with MHC-I expressed on other cells. However, the inhibitory Ly49A receptor can also bind MHC-I ligand on the NK cell itself (in cis). Here we describe a Ly49A variant, which can engage MHC-I expressed on other cells but not in cis. Even though this variant inhibited NK cell effector function, it failed to educate NK cells. The association with MHC-I in cis sequestered wild-type Ly49A, and this was found to relieve NK cells from a suppressive effect of unengaged Ly49A. These data explain how inhibitory MHC-I receptors can facilitate NK cell activation. They dissociate classical inhibitory from educating functions of Ly49A and suggest that cis interaction of Ly49A is necessary for NK cell education.
Keywords
Animals, Cell Line, Tumor, Cells, Cultured, Flow Cytometry, Genetic Variation, Histocompatibility Antigens Class I/metabolism, Killer Cells, Natural/immunology, Lymphocyte Activation/immunology, Mice, Mice, Inbred C57BL, NK Cell Lectin-Like Receptor Subfamily A/genetics, NK Cell Lectin-Like Receptor Subfamily A/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
19/01/2010 15:52
Last modification date
20/08/2019 14:48
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